FPGEE 시험 - NABP실제시험문제와 답 - 426문항

Question No : 1

Which of the following Cytochrome P450 isozymes is responsible for the bulk of phase I metabolism?

A.CYP1A2
B.CYP2C9
C.CYP2D6
D.CYP3A4
E.CYP51

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Question No : 2

In a zero order elimination process, which of the following is true?

A.The removal of drug is independent of drug concentration
B.Cl = Elimination rate/Cp
C.t1/2 = .7VD/Cl
D.All are true

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Question No : 3

Bioavailability is related to which of the following parameters, according to the equation F = 1 - E

A.Excretion
B.Elimination
C.Extraction Ratio
D.Enterohepatic Recycling

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Question No : 4

Which of the following statements refers to HPMPC?

A.Tricyclic.
B.Cytosine monophosphate analog
C.Works by accumulating in and changing pH of lysosomes.
D.Mild intrinsic sympathomimetic activity - does not decrease heart rate and contractility as much during exercise.
E.Metabolized in liver by P450.

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Question No : 5

Mechanism of action of zalcitabine is:

A.Inhibits inosine monophosphate dehydrogenase
B.Inhibits reverse transcriptase
C.Inhibits DNA gyrase
D.Inhibits viral protease
E.Inhibits dihydropteroate synthetase

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Question No : 6

A drug ending in the suffix (navir) is considered a ______.

A.Antidepressant
B.Protease inhibitor
C.Beta antagonist
D.H2 antagonist

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Question No : 7

Given that the VD = 230 L/70Kg and Cl = 60 L/hr/70 Kg for morphine, approximately how much of a 10 mg IV dose remains after 8 hr, given to a normal 70 Kg patient?

A.5 mg
B.2.5 mg
C.1.25 mg
D.625 mg

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Question No : 8

Route of excretion of cinoxacin is:

A.Unknown
B.Kidneys
C.Intestines
D.Liver

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Question No : 9

Route of administration of ofloxacin is:

A.Intra-auricular
B.Sublingual
C.Oral
D.IV
E.Intramuscular

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Question No : 10

Subclass of lomafloxacin is:

A.Fluoroquinolones
B.IA
C.Calciferols
D.Beta-lactamase resistant penicillins
E.Aldosterone antagonists

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Question No : 11

Mechanism of action of FK506 is:

A.Reduces calcium influx into neurons
B.Inhibits calcineurin
C.Inhibits phospholipase C
D.Inhibits phospholipid synthesis
E.Induces DNA damage under anaerobic conditions

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Question No : 12

Effect of cascara is:

A.Decreases water absorption
B.Stimulates segmentation
C.Decreases meal-stimulated gastric acid secretion
D.May increase triglycerides
E.Afterload increase

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Question No : 13

Class of nitrogen mustard is:

A.Aquaretics
B.Alkylating agents
C.Lipid lowering drugs
D.Drugs affecting calcium homeostasis
E.Antivirals

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Question No : 14

Which of the following is considered a class IA Sodium Channel blocker?

A.Propafenone
B.Disopyramide
C.Aminodarone
D.Quinidine

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Question No : 15

Which of the following statements refers to buspirone?

A.Fatal overdosage rare unless taken with alcohol or other CNS depressants.
B.Choice between quinidine and disopyramide should be made based on side effects. In patients with AV conduction problems or quinidine-induced GI toxicity, disopyramide ought to be chosen. In patients with MI or anticholinergic side effects, quinidine is the agent of choice.
C.Less effective than tricyclics or ECT in unipolar depression.
D.Is metabolized to several substances with long (>24 hours) half lives. These do not contribute to anticonvulsant effect but do contribute to sedative effect.
E.No difference in effects between elderly and average population

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NABP FPGEE 시험